Set in the 1920s. A young English couple, Walter a middle class doctor and Kitty, an upper-class woman, get married for all the wrong reasons and relocate to Shanghai. Kitty falls in love with someone else. When Walter discovers her infidelity, in an act of vengeance, he accepts a job in a remote village in China that is being ravaged by a deadly epidemic. He takes his wife along and their journey brings meaning to their relationship and gives them purpose in one of the most remote and beautiful places on earth.